Yes, oleander (Nerium oleander) is considered highly deer-resistant. This resistance is not due to thorns or an unpleasant texture but is instead rooted in the plant's potent chemical defense system. Oleander contains a suite of toxic cardiac glycosides, such as oleandrin and nerioside, throughout all parts of the plant—leaves, stems, flowers, and even the sap. These compounds are extremely bitter and cause severe irritation to the mucous membranes of mammals. When a deer samples an oleander, it experiences an immediate and aversive reaction, teaching the animal to avoid the plant in the future. This makes it an excellent choice for landscapes in areas with high deer pressure.
It is crucial to understand that the term "deer-resistant" is not synonymous with "deer-proof." No plant is entirely safe under all conditions. In times of extreme hunger or drought, when preferred food sources are scarce, deer may sample plants they would normally avoid. This is known as "browsing pressure," and a desperate deer might nibble on oleander. However, due to its immediate and severe toxicity, this is exceptionally rare. The deer is unlikely to return for a second bite. The level of resistance can also vary slightly by region and the local deer population's acquired tastes, but oleander consistently ranks among the most reliably resistant plants.
While oleander's toxicity is a boon for deterring deer, it introduces significant safety considerations for the landscaper and household. All parts of the plant are poisonous to humans, dogs, cats, horses, and other livestock. Ingestion of even a small amount of leaf material can be fatal. Therefore, it should be planted with caution. Avoid placing it in areas accessible to curious children or pets. Do not use the twigs for skewering food for barbecues, and never burn oleander clippings, as the smoke can irritate the lungs and cause a toxic reaction. Always wear gloves when pruning and wash your hands thoroughly afterward to avoid contact with the sap.
To maximize the effectiveness of oleander as a deer deterrent, use it strategically within your landscape design. Employ it as a foundation planting around the perimeter of your property or in areas that are most vulnerable to deer intrusion. For the greatest protection, integrate it into a layered planting scheme with other deer-resistant shrubs and perennials. This creates a "wall" of unpalatable plants that discourages deer from entering the space. Excellent companion plants include Russian sage (Perovskia atriplicifolia), lavender (Lavandula), bearded iris, and ornamental grasses. This diversity not only enhances beauty but also strengthens the overall defensive strategy of your garden.